Valosin-containing protein regulates the stability of amyotrophic lateral sclerosis-causing fused in sarcoma granules in cells by changing ATP concentrations inside the granules
K. Yasuda, T. M. Watanabe, M.-G. Kang, J. K. Seo, H.-W. Rhee, S.-i. Tate
This study shows VCP regulates FUS granule stability by consuming ATP inside the granules, acting as a timer to prevent persistent granules that lead to ALS pathology.
bioRxiv · Dec 24, 2021 · PreprintCell Biology