Author

T. M. Watanabe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:imaging· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

H. Fujita· 2 shared J. Kaneshiro· 2 shared T. Ichimura· 2 shared Y. Okada· 2 shared A. Germond· 1 shared A. H. Iwane· 1 shared A. Kasai· 1 shared A. Kimura· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

H. Fujita

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation

T. M. Watanabe, H. Fujita, J. Kaneshiro, M. Takeda, K. Sasaki, R. Yamamoto, D. Umetsu, E. Kuranaga, S. Higo, T. Kondo, Y. Asano, Y. Sakata, S. Miyagawa

This paper develops a method to estimate crossbridge-state in cardiomyocytes using SHG polarization, showing its applicability in assessing myosin force generation and drug effects.

bioRxiv · Oct 13, 2022Biophysics

Single-molecule tracking of Nanog and Oct4 in mouse embryonic stem cells

K. Okamoto, H. Fujita, Y. Okada, S. Onami, S. Shinkai, K. Abe, K. Fujimoto, T. M. Watanabe

The paper tracks Nanog and Oct4 in mouse embryonic stem cells to study their roles in pluripotency, finding that Nanog interacts longer with targets during differentiation, suggesting a feedback mechanism.

bioRxiv · Aug 8, 2022 · PreprintBiophysics

Valosin-containing protein regulates the stability of amyotrophic lateral sclerosis-causing fused in sarcoma granules in cells by changing ATP concentrations inside the granules

K. Yasuda, T. M. Watanabe, M.-G. Kang, J. K. Seo, H.-W. Rhee, S.-i. Tate

This study shows VCP regulates FUS granule stability by consuming ATP inside the granules, acting as a timer to prevent persistent granules that lead to ALS pathology.

bioRxiv · Dec 24, 2021 · PreprintCell Biology

Exploring rare cellular activity in more than one million cells by a trans-scale-scope

T. Ichimura, T. Kakizuka, K. Horikawa, K. Seiriki, A. Kasai, H. Hashimoto, K. Fujita, T. M. Watanabe, T. Nagai

The paper introduces an imaging system to observe rare cellular activity in over one million cells and demonstrates its ability to detect rare events in biological systems.

bioRxiv · Jun 29, 2020 · PreprintCell Biology

Multiplexed 129Xe HyperCEST MRI detection of genetically-reconstituted bacterial protein nanoparticles in human cancer cells.

R. Mizushima, K. Inoue, H. Fujiwara, A. H. Iwane, T. M. Watanabe, A. Kimura

The paper genetically reconstitutes bacterial protein nanoparticles in human cancer cells and demonstrates their use as contrast agents for HyperCEST MRI.

bioRxiv · Jan 30, 2020Biophysics

Pairwise Efficiency: A new mathematical approach to qPCR data analysis increases the precision of the classical calibration curve assay

Y. Panina, A. Germond, G. B. David, T. M. Watanabe

This paper introduces a new mathematical approach to qPCR data analysis that improves the precision of efficiency and gene expression ratio estimations compared to the classical calibration curve method.

bioRxiv · Aug 24, 2018Biochemistry

Second harmonic generation polarization microscopy as a tool for protein structure analysis

J. Kaneshiro, Y. Okada, T. Shima, M. Tsujii, K. Imada, T. Ichimura, T. M. Watanabe

This paper demonstrates the use of SHG polarization microscopy to detect protein conformational changes in macromolecular assemblies without labeling.

bioRxiv · Jun 4, 2018Biophysics