H.-W. Rhee

Mitochondrial thermogenesis regulates heat-shock response in the nucleus

The paper shows mitochondrial thermogenesis generates heat that triggers a nuclear heat-shock response in mammalian cells.

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

This study identifies FKBP8 as the tethering partner of PDZD8 at ER-mitochondria contact sites, showing their interdependence in regulating mitochondrial morphology.

Valosin-containing protein regulates the stability of amyotrophic lateral sclerosis-causing fused in sarcoma granules in cells by changing ATP concentrations inside the granules

This study shows VCP regulates FUS granule stability by consuming ATP inside the granules, acting as a timer to prevent persistent granules that lead to ALS pathology.

In vivo mitochondrial matrix proteome profiling reveals RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

Endomembrane systems are reorganized by ORF3a and Membrane (M) of SARS-CoV-2

This study identifies ORF3a and M proteins of SARS-CoV-2 as reorganizing the endoplasmic reticulum and mitochondrial-associated membrane, with potential therapeutic implications.

Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

The paper introduces iSLET, a method to track tissue-specific secretory proteins in live mice, demonstrating its use in labeling and identifying liver-specific secreted proteomes in blood plasma.

Split-TurboID enables contact-dependent proximity labeling in cells

Split-TurboID enables proximity labeling at organelle contact sites by splitting the TurboID enzyme and reconstituting it at these sites, identifying over 100 endogenous proteins.

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

This study identifies NSUN2 as a methyltransferase introducing 5-methylcytosine in mitochondrial tRNAs and shows its necessity for m5C modification but not for tRNA stability or oxidative phosphorylation in differentiated cells.