Author

M.-H. Hsiao

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. F. Rubin· 1 shared B. Wang· 1 shared C. E. Gonzalez· 1 shared D. Rohm· 1 shared E.-Y. Tsou· 1 shared F. W. Stearns· 1 shared J. D. Mehlhoff· 1 shared M. Ostermeier· 1 shared

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2020-2020 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperEvolutionary Biology

A. F. Rubin

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1 paper

Recent·Most cited

Collateral fitness effects of mutations

J. D. Mehlhoff, F. W. Stearns, D. Rohm, B. Wang, E.-Y. Tsou, N. Dutta, M.-H. Hsiao, C. E. Gonzalez, A. F. Rubin, M. Ostermeier

This study identifies collateral fitness effects of mutations in E. coli, showing that 42% of missense mutations in TEM-1 β-lactamase are deleterious through mechanisms unrelated to protein function.

bioRxiv · Mar 4, 2020Evolutionary Biology