Author

J. D. Mehlhoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Evolutionary Biology· 2

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Ostermeier· 2 shared A. F. Rubin· 1 shared B. Wang· 1 shared C. E. Gonzalez· 1 shared D. Rohm· 1 shared E.-Y. Tsou· 1 shared F. W. Stearns· 1 shared M.-H. Hsiao· 1 shared

Activity by Year

2020-2023 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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2 shared papersEvolutionary Biology

M. Ostermeier

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2 papers

Recent·Most cited

Genes vary greatly in their propensity for collateral fitness effects of mutations

J. D. Mehlhoff, M. Ostermeier

The paper uses deep mutational scanning to show that different genes have varying propensities for mutations causing collateral fitness effects, with TEM-1 showing the highest rate.

Molecular Biology and Evolution · Mar 4, 2023Peer-reviewedEvolutionary Biology

Collateral fitness effects of mutations

J. D. Mehlhoff, F. W. Stearns, D. Rohm, B. Wang, E.-Y. Tsou, N. Dutta, M.-H. Hsiao, C. E. Gonzalez, A. F. Rubin, M. Ostermeier

This study identifies collateral fitness effects of mutations in E. coli, showing that 42% of missense mutations in TEM-1 β-lactamase are deleterious through mechanisms unrelated to protein function.

bioRxiv · Mar 4, 2020Evolutionary Biology