Pharmacology & ToxicologybioRxivPreprint
The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias
M.-H. M. Tsai, L. Chen, M. H. Baumann…·L. Shi
This study evaluates the in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor, finding that high intrinsic efficacy in Gi signaling correlates with increased risk of intoxication, regardless of signaling bias.
DOI 10.1101/2023.11.10.566672