J. R. Lane

The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias

This study evaluates the in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor, finding that high intrinsic efficacy in Gi signaling correlates with increased risk of intoxication, regardless of signaling bias.

PspA-mediated aggregation protects Streptococcus pneumoniae against desiccation on fomites

This study shows PspA-mediated aggregation of Streptococcus pneumoniae enhances desiccation survival on fomites and transmission to new hosts.

Influenza A virus modulation of Streptococcus pneumoniae infection using ex vivo transcriptomics in a human primary lung epithelial cell model reveals differential host glycoconjugate uptake and metabolism

This study uses ex vivo transcriptomics to show that influenza A virus infection enhances pneumococcal growth and alters bacterial metabolism in human lung epithelial cells.

Identification and Characterization of ML321: a Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models that Predict Atypical Antipsychotic Activity

This paper develops ML321, a highly selective D2 dopamine receptor antagonist, showing efficacy in animal models predictive of atypical antipsychotic activity with fewer side effects.

Distinct antagonist-bound inactive states underlie the divergence in the structures of the dopamine D2 and D3 receptors

The paper identifies distinct antagonist-bound inactive states in dopamine D2 and D3 receptors, showing conformational diversity with implications for drug discovery.