Author

M. Canals

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. R. Lane· 2 shared A. Batista-Gondin· 1 shared B. Kemp-Harper· 1 shared C. Hoffmann· 1 shared H. Lim· 1 shared J. A. Javitch· 1 shared J. Drube· 1 shared J. E. Pease· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

J. R. Lane

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3 papers

Recent·Most cited

The Chemokine Receptor CCR8 is Not a High-affinity Receptor for the Human Chemokine CCL18

K. Hussain, H. Lim, S. R. Devkota, B. Kemp-Harper, J. R. Lane, M. Canals, J. E. Pease, M. J. Stone

The paper investigates whether CCR8 is a high-affinity receptor for CCL18 and finds that CCR8 does not respond to CCL18 in multiple assays.

bioRxiv · May 30, 2024Immunology

Key phosphorylation sites for robust β-arrestin2 binding at the mu-opioid receptor revisited

O. Underwood, S. Frizwanker, J. Glenn, A. Batista-Gondin, J. Drube, C. Hoffmann, S. J. Briddon, S. S. Schulz, M. Canals

The paper investigates the role of GRK subfamilies in phosphorylation of the MOR C-tail and their impact on β-arrestin2 recruitment, showing GRK2/3 and GRK5/6 have distinct contributions.

bioRxiv · Dec 5, 2023 · PreprintPharmacology & Toxicology

The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias

M.-H. M. Tsai, L. Chen, M. H. Baumann, M. Canals, J. A. Javitch, J. R. Lane, L. Shi

This study evaluates the in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor, finding that high intrinsic efficacy in Gi signaling correlates with increased risk of intoxication, regardless of signaling bias.

bioRxiv · Nov 10, 2023 · PreprintPharmacology & Toxicology