SARS-CoV-2 variants show temperature-dependent enhanced polymerase activity in the upper respiratory tract and high transmissibility
S.-M. Kim, E.-H. Kim, M. A. B. Casel, Y.-i. Kim, R. Sun, M.-J. Kwack, J.-S. Yoo, M.-A. Yoo, K.-M. Yoo, S.-G. Jang, R. Rollon, J. H. Choi, J. Gil, K. Eun, H. Kim, , Y. K. Choi
This study shows SARS-CoV-2 variants with P323L or P323L/G671S mutations in NSP12 have enhanced polymerase activity at 33°C and higher transmissibility in ferrets.
bioRxiv · Sep 27, 2022 · PreprintMicrobiology