Author

Y. K. Choi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7 Microbiology· 5 Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:drug response / drug discovery· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Approach:statistical model· 4 Assay:structural biology· 3 Organism:virus· 3 Approach:deep learning· 2

Frequent Co-Authors

W. Im· 7 shared S.-J. Park· 4 shared Y.-i. Kim· 4 shared C. Seok· 3 shared H. Woo· 3 shared J. Lee· 3 shared J. U. Jung· 3 shared M. S. Yeom· 3 shared

Activity by Year

2020-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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7 shared papersBiophysics

W. Im

Mutual co-authors in cluster

Author profile →

15 papers

Recent·Most cited

CHARMM-GUI Multicomponent Assembler for Modeling and Simulation of Complex Multicomponent Systems

N. R. Kern, J. Lee, Y. K. Choi, W. Im

The paper introduces a tool for automated molecular assembly under periodic boundary conditions, demonstrating its application on six complex systems.

bioRxiv · Aug 30, 2023Biophysics

Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie Bandavirus in aged ferrets

J. U. Jung, D. Kim, E. Kim, S. Kim, Y. Chung, S.-D. Cho, Y. Choi, C.-J. Lai, X. Dai, S. Kang, M.-J. Kwak, I. Cha, Z. Liu, Y. Choi, S.-H. Park, , S. Kim

This paper develops a self-assembling ferritin nanoparticle vaccine targeting DBV Gn head region that fully protects aged ferrets from lethal DBV challenge.

bioRxiv · Jul 19, 2023Microbiology

Anillin Related Mid1 as an Adaptive and Multimodal Contractile Ring Anchoring Protein: A Simulation Study

A. R. Hall, Y. K. Choi, W. Im, D. Vavylonis

This study simulates Mid1's membrane binding mechanisms, showing multiple binding modes involving its PH and C2 domains, and how these contribute to its role in cytokinetic ring anchoring.

bioRxiv · Jan 27, 2023Biophysics

SARS-CoV-2 variants show temperature-dependent enhanced polymerase activity in the upper respiratory tract and high transmissibility

S.-M. Kim, E.-H. Kim, M. A. B. Casel, Y.-i. Kim, R. Sun, M.-J. Kwack, J.-S. Yoo, M.-A. Yoo, K.-M. Yoo, S.-G. Jang, R. Rollon, J. H. Choi, J. Gil, K. Eun, H. Kim, , Y. K. Choi

This study shows SARS-CoV-2 variants with P323L or P323L/G671S mutations in NSP12 have enhanced polymerase activity at 33°C and higher transmissibility in ferrets.

bioRxiv · Sep 27, 2022 · PreprintMicrobiology

From Molecular Dynamics to Supramolecular Organization: The Role of PIM Lipids in the Originality of the Mycobacterial Plasma Membrane

C. M. Brown, R. A. Corey, Y. Gao, Y. K. Choi, M. Gilleron, N. Destainville, E. Fullam, W. Im, P. J. Stansfeld, M. Chavent

This paper uses molecular dynamics simulations to study the role of PIM lipids in the structure and organization of the Mycobacterial plasma membrane and validates findings with drug testing.

bioRxiv · Jun 29, 2022Biophysics

Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice

J. H. Jeong, S. Chokkakula, S. C. Min, B. Kim, W.-S. Choi, S. Oh, Y. S. Yun, D. H. Kang, O.-J. Lee, E.-G. Kim, J.-H. Choi, J.-Y. Lee, Y. K. Choi, Y. H. Baek, M.-S. Song

This paper evaluates combination antiviral therapies in SARS-CoV-2 infected mice, finding that nirmatrelvir and molnupiravir together significantly improve survival compared to monotherapies.

bioRxiv · Jun 27, 2022Microbiology

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

A. Zheng, Z. Zhang, G. Zhang, X. Zhan, X. Zhang, C. Zhao, C. Cheng, H. Li, T. Yu, K. Lawrence, J. Sun, Z. Yang, L. Ye, H. Chu, Y. Wang, , Y. K. Choi

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

bioRxiv · Oct 20, 2021 · PreprintEvolutionary Biology

CHARMM-GUI Membrane Builder for Lipid Nanoparticles with Ionizable Cationic Lipids and PEGylated Lipids

S. Park, Y. K. Choi, S. Kim, J. Lee, W. Im

The paper extends CHARMM-GUI Membrane Builder to model and simulate lipid nanoparticles with ionizable cationic lipids and PEGylated lipids, showing how PEG-lipids affect membrane structure and dynamics.

bioRxiv · Jun 23, 2021Biophysics

Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies

Y. Cao, Y. K. Choi, M. Frank, H. Woo, S.-J. Park, M. S. Yeom, C. Seok, W. Im

This study uses molecular dynamics simulations to analyze SARS-CoV-2 spike protein interactions with antibodies, revealing structural dynamics and mutation impacts on neutralization.

bioRxiv · May 10, 2021Biophysics

Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant

S.-Y. Lee, D.-K. Ryu, Y. K. Choi, P. Moore, C. A. v. Baalen, r. song, A. S. Tijsma, T. Gwete-Moyo, M. Kim, Y.-I. Kim, C. Kim, J.-I. Kim, K.-S. Kwon

This study evaluates CT-P59's efficacy against SARS-CoV-2 variants, showing reduced in vitro neutralization but effective in vivo therapeutic potential against the B.1.351 variant.

bioRxiv · Apr 27, 2021Microbiology

Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018

N. van Doremalen, M. C. Letko, R. Fischer, T. Bushmaker, K. C. Yinda, J. Schulz, S. N. Seifert, N. J. Kim, M. G. Hemida, G. Kayali, W. B. Park, R. Perera, A. Tamin, N. J. Thornburg, S. Tong, , V. Munster

The paper examines the environmental stability, replication kinetics, and pathogenicity of diverse MERS-CoV strains and SARS-CoV-2, finding variation in stability and pathogenicity among isolates.

bioRxiv · Feb 11, 2021 · PreprintMicrobiology

Development of spike receptor-binding domain nanoparticle as a vaccine candidate against SARS-CoV-2 infection in ferrets

Y.-I. Kim, D. Kim, K.-M. Yu, H. D. Seo, S.-A. Lee, M. A. B. Casel, S.-G. Jang, S. Kim, W. Jung, C.-J. Lai, Y. K. Choi, J. U. Jung

This study develops a RBD-based nanoparticle vaccine against SARS-CoV-2 that protects ferrets from infection and reduces viral load.

bioRxiv · Jan 28, 2021Immunology

Single-cell Transcriptome of Bronchoalveolar Lavage Fluid Reveals Dynamic Change of Macrophages During SARS-CoV-2 Infection in Ferrets

J. S. Lee, J.-Y. Koh, K. Yi, Y.-I. Kim, S.-J. Park, E.-H. Kim, S.-M. Kim, S. H. Park, Y. S. Ju, Y. K. Choi, S.-H. Park

This study uses single-cell RNA sequencing to track macrophage dynamics in SARS-CoV-2-infected ferrets over time, revealing distinct subpopulations and functional changes.

bioRxiv · Nov 18, 2020Immunology

Structure, Dynamics, Receptor Binding, and Antibody Binding of Fully-glycosylated Full-length SARS-CoV-2 Spike Protein in a Viral Membrane

Y. K. Choi, Y. Cao, M. Frank, H. Woo, S.-J. Park, M. S. Yeom, T. I. Croll, C. Seok, W. Im

This study uses molecular dynamics simulations to analyze the structure, dynamics, and antibody binding of the fully-glycosylated SARS-CoV-2 spike protein, revealing key roles of glycans in stabilizing RBD conformations and antibody epitope exposure.

bioRxiv · Oct 18, 2020Biophysics

Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane

H. Woo, S.-J. Park, Y. K. Choi, T. Park, M. Tanveer, Y. Cao, N. R. Kern, J. Lee, M. S. Yeom, T. I. Croll, C. Seok, W. Im

The paper models and simulates a fully-glycosylated SARS-CoV-2 spike protein in a viral membrane using computational methods and provides the structures for research on COVID-19 prevention and treatment.

bioRxiv · May 20, 2020Biophysics