Pogz deficiency leads to abnormal behavior, transcription dysregulation and impaired cerebellar physiology
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer‐Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo‐Jen Huang, Koh‐ichi Nagata, Yosef Yarom, Sagiv Shifman
This study shows that Pogz deficiency in mice causes brain abnormalities, transcription dysregulation, and cerebellar dysfunction resembling ASD features in humans.
Nature Communications · Nov 17, 2020Peer-reviewedGenetics