Sagiv Shifman

The paper identifies rRNA methylation dynamics as a mechanism regulating translation efficiency and HSC fitness during hematopoietic differentiation.

This study shows that germline manipulation in killifish leads to sex-specific effects on longevity and repair mechanisms.

The paper introduces MoToCC, a method to identify critical cell-types associated with neurodevelopmental disorders using genetic modules and single-cell data.

The paper identifies 178 genes with sex-dependent essentiality in cancer cell lines by analyzing CRISPR screens and integrating with gene expression and mutation data.

The paper shows that ROW cooperates with BEAF-32 to regulate long-range transcription through chromatin loops at TAD boundaries.

The paper identifies lineage-specific essential genes (LSEGs) through CRISPR screens and explores mechanisms like gene amplification and paralog expression that contribute to tissue-specific essentiality.

This study shows that Pogz deficiency in mice causes brain abnormalities, transcription dysregulation, and cerebellar dysfunction resembling ASD features in humans.

The paper identifies essential genes in mouse embryonic stem cells and links them to neurodevelopmental disorders in humans.

The paper develops ImReP, a computational method to profile TCR and BCR repertoires from RNA-seq data, creating a large atlas of immunological sequences across 53 tissues.

This paper introduces ROP to identify the source of unmapped RNA-Seq reads across diverse tissues, showing it can account for 99.9% of 1 trillion reads and reveals immune and microbial correlations.

The paper develops a method to infer allelic heterogeneity in GWAS and eQTL datasets, identifying 4152 loci with strong evidence of AH across different traits.

The paper shows that different mutation classes affect distinct pathways in neuropsychiatric disorders, explaining genetic convergence and specific gene expression patterns across ID, ASD, and SCZ.