A human cytomegalovirus prefusion-like glycoprotein B subunit vaccine elicits similar humoral immunity to that of postfusion gB in mice
Krithika P. Karthigeyan, Megan Connors, Christian R. Binuya, Mackensie Gross, Adelaide S. Fuller, Chelsea M. Crooks, Hsuan-Yuan Wang, Madeline R. Sponholtz, Patrick O. Byrne, Savannah L. Herbek, Caroline Andy, Linda M. Gerber, John D. Campbell, Caitlin A. Williams, Elizabeth O. Mitchell, , Sallie R. Permar
This study compares humoral immunity elicited by prefusion-like and postfusion forms of HCMV gB in mice, finding similar neutralization titers but differences in antibody binding and phagocytosis.
Journal of Virology · May 8, 2025Peer-reviewedImmunology