Sallie R. Permar

This study shows that HCMV glycoprotein B, not the pentameric complex, is a target of antibody-mediated phagocytosis, suggesting gB should be prioritized for vaccines against vertical transmission.

The paper identifies gH/UL116 as a target for antibodies that neutralize HCMV and activate FcγR, showing its potential as a vaccine candidate.

This paper introduces a designed nanofiber immunogen platform that primes antibodies with increased conformational tolerance toward HIV-1 fusion peptide, showing efficacy in mice and infant non-human primates.

This study compares acute infection and viral rebound dynamics in ART-treated infant rhesus macaques using a mathematical model to identify increased infected cell death during rebound.

The paper identifies a mechanism by which commensal bacteria inhibit viral infections through a tryptophan metabolite that activates the aryl hydrocarbon receptor.

This study compares neutralization susceptibility of clade C HIV viruses from breastmilk to those from sexual transmission, finding breastmilk viruses more resistant to certain broadly neutralizing antibodies.

This study compares bnAb precursor responses in infant and juvenile rhesus macaques after germline-targeting HIV Env immunization, finding higher rates in infants.

This study compares humoral immunity elicited by prefusion-like and postfusion forms of HCMV gB in mice, finding similar neutralization titers but differences in antibody binding and phagocytosis.

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

The nonhuman primate model mirrors the epidemiology of human congenital CMV (cCMV) after primary infection and reveals its transmission bottlenecks.

This paper describes the stabilization of HCMV gB in a prefusion-like conformation using structure-based design and shows similar neutralizing antibody titers against postfusion and prefusion forms.

This study examines how early ART initiation in HIV-infected infants affects antibody development and latent reservoir dynamics, showing their opposing impacts on post-treatment viral rebound.

This paper evaluates three clade C SHIVs for oral transmission and infection in infant rhesus macaques, finding varied chronic viremia levels and seroconversion thresholds.

This study identifies factors affecting placental IgG transfer efficiency in HIV-infected women, showing that maternal disease progression and Fc region characteristics influence selective transfer of antigen-specific IgG.

The paper identifies infant-transmitted HIV-1 variants that are neutralization-resistant to maternal plasma but sensitive to broadly neutralizing antibodies, suggesting maternal antibody responses select for these resistant variants during peripartum transmission.