Chelsea M. Crooks

This study shows that HCMV glycoprotein B, not the pentameric complex, is a target of antibody-mediated phagocytosis, suggesting gB should be prioritized for vaccines against vertical transmission.

The paper identifies gH/UL116 as a target for antibodies that neutralize HCMV and activate FcγR, showing its potential as a vaccine candidate.

This study infects pregnant rhesus macaques with Spondweni virus and finds placental pathology without fetal harm, contrasting with ZIKV-DAK-induced fetal demise.

This study compares humoral immunity elicited by prefusion-like and postfusion forms of HCMV gB in mice, finding similar neutralization titers but differences in antibody binding and phagocytosis.

The nonhuman primate model mirrors the epidemiology of human congenital CMV (cCMV) after primary infection and reveals its transmission bottlenecks.

This paper describes the stabilization of HCMV gB in a prefusion-like conformation using structure-based design and shows similar neutralizing antibody titers against postfusion and prefusion forms.