Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension
Justin H. Berger, Yuji Shi, Timothy R. Matsuura, Kirill Batmanov, Xian Chen, Kelly Tam, Mackenzie Marshall, Richard Kue, Jiten D. Patel, Renee Taing, Russell Callaway, Joanna Griffin, Attila Kovács, Dinesh K. Hirenallur-Shanthappa, Russell Miller, , Daniel P. Kelly
This paper develops a two-hit mouse model of HFpEF combining diet-induced obesity and renin-mediated hypertension, showing key features of the disease and response to therapy.
Scientific Reports · Jan 2, 2025Peer-reviewedPhysiology