Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis
Madeleine Delbeau, Expery O. Omollo, Ruby Froom, Steven Koh, Rachel Anne Mooney, Mirjana Lilić, Joshua J. Brewer, Jeremy M. Rock, Seth Andrew Darst, Elizabeth A. Campbell, Robert C. Landick
This study identifies MtbNusG as a pro-pausing transcription factor that stabilizes paused RNAP through specific structural interactions, with implications for NusG function across domains of life.
bioRxiv · Oct 21, 2022 · PreprintMolecular Biology