Jeremy M. Rock

This study identifies outer membrane porins as phage-specific determinants of mycobacterial susceptibility through a CRISPRi screen in Mycobacterium smegmatis.

The paper uses AI-based protein-protein interaction predictions to characterize protein function in mycobacterial pathogens, identifying key interactions and functions for previously uncharacterized proteins.

The paper identifies Rv2571c as a mycobacterial ion channel that mediates pyrazinamide resistance by regulating cytoplasmic acidification.

This study identifies TapA as a regulator of cell separation and intrinsic drug resistance in Mycobacterium tuberculosis by controlling the transition between division and pole growth.

This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.

The paper performs a genome-wide CRISPRi screen in Mycobacterium smegmatis to uncover novel gene functions and drug targets related to the cell envelope.

The paper maps unknown lipids in bacterial pathogens using lipidomic methods, revealing new biosynthetic products linked to virulence.

This paper introduces CRISPRi-DR, a dose-response model to analyze chemical-genetic interactions in CRISPRi screens, showing improved precision over existing methods.

This study identifies MtbNusG as a pro-pausing transcription factor that stabilizes paused RNAP through specific structural interactions, with implications for NusG function across domains of life.