Author

Madeleine Graef

University Hospital Bonn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Eva BartokiD· 1 shared Felix BenderiD· 1 shared Georg NickenigiD· 1 shared Gunther HartmanniD· 1 shared Jasper SpitzeriD· 1 shared Katharina Isabell MaseriD· 1 shared Kevin ThurleyiD· 1 shared Lisa Maria SteinheueriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Eva BartokORCID

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1 paper

Recent·Most cited

Mechanical stress-induced release of mitochondrial double-stranded RNA activates RIG-I to drive osteogenic differentiation in aortic disease

Madeleine Graef, Felix Bender, Svenja Dudek, Paraskevi Vasileiadou, Sofía Soler, Thais Marina Schlee-Guimaraes, Lisa Maria Steinheuer, Jasper Spitzer, Kevin Thurley, Radosław P. Nowak, Katharina Isabell Maser, Susanne Schmidt, Philip R Goody, Martin Schlee, Sebastian Zimmer, , Gunther Hartmann

This study shows mechanical stress releases mitochondrial dsRNA, activating RIG-I to drive osteogenic differentiation and calcification in aortic disease, with JAK/STAT inhibition offering therapeutic potential.

bioRxiv · Oct 29, 2026 · PreprintCell Biology