Radosław P. Nowak

Mechanical stress-induced release of mitochondrial double-stranded RNA activates RIG-I to drive osteogenic differentiation in aortic disease

This study shows mechanical stress releases mitochondrial dsRNA, activating RIG-I to drive osteogenic differentiation and calcification in aortic disease, with JAK/STAT inhibition offering therapeutic potential.

Systematic Targeting of Protein Complexes with Molecular COUPLrs

The paper introduces molecular COUPLrs to systematically target protein complexes, identifying new glue classes and their interactions in cancer cell lines.

Activating p53Y220C with a Mutant-Specific Small Molecule

This paper develops a small molecule, TRAP-1, that activates mutant p53 by forming a ternary complex with BRD4, leading to p53 target gene upregulation and inhibition of cancer cell growth.

Leveraging the BAF chromatin remodeling complex for targeted transcriptional rewiring in cancer

This paper introduces TRIPs, neomorphic molecules that recruit BAF complexes to rewire BCL6 in DLBCL, inducing apoptosis through chromatin remodeling.

ProxiCapture Reveals Context-Dependent CRBN Interactome Landscape of Molecular Glue Degraders

ProxiCapture identifies context-dependent CRBN interactors of molecular glues across diverse cell types and tissues, revealing a comprehensive atlas of pomalidomide targets.

Decoding protein-peptide interactions using a large, target-agnostic yeast surface display library

The paper develops a large yeast surface display library to identify high-affinity peptide ligands for various protein targets, revealing binding motifs and novel clones.

E3-specific degrader discovery by dynamic tracing of substrate receptor abundance

This paper develops a scalable method to identify E3-specific degraders by tracing substrate receptor abundance changes induced by pharmacological auto-degradation.