Sebastian Zimmer

This study shows mechanical stress releases mitochondrial dsRNA, activating RIG-I to drive osteogenic differentiation and calcification in aortic disease, with JAK/STAT inhibition offering therapeutic potential.

This study shows that activating perivascular thermogenic fat reduces aortic stenosis in mice and correlates with less severe AS in humans.

This study shows vitamin K2 reduces ferroptosis-driven lipid peroxidation and slows aortic valve stenosis progression in both human and mouse models.

This study identifies epigenomic changes in circulating T cells associated with aortic valve stenosis, showing a methylation risk score correlates with hemodynamic severity.