Author

Thais Marina Schlee-Guimaraes

University Hospital BonnORCID 0000-0002-3710-6322Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1

Frequent Co-Authors

Gunther HartmanniD· 2 shared Martin SchleeiD· 2 shared Alexander KirchhoffiD· 1 shared Alexey StukaloviD· 1 shared Andreas PichlmairiD· 1 shared Antonio PirasiD· 1 shared Caroline C. FriedeliD· 1 shared Christian UrbaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

Gunther HartmannORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Mechanical stress-induced release of mitochondrial double-stranded RNA activates RIG-I to drive osteogenic differentiation in aortic disease

Madeleine Graef, Felix Bender, Svenja Dudek, Paraskevi Vasileiadou, Sofía Soler, Thais Marina Schlee-Guimaraes, Lisa Maria Steinheuer, Jasper Spitzer, Kevin Thurley, Radosław P. Nowak, Katharina Isabell Maser, Susanne Schmidt, Philip R Goody, Martin Schlee, Sebastian Zimmer, , Gunther Hartmann

This study shows mechanical stress releases mitochondrial dsRNA, activating RIG-I to drive osteogenic differentiation and calcification in aortic disease, with JAK/STAT inhibition offering therapeutic potential.

bioRxiv · Oct 29, 2026 · PreprintCell Biology

mRNA N1-2'O-methylation by CMTR1 affects NVL2 mRNA splicing

Steven Wolter, Thomas Hennig, Christina Wallerath, Thais Marina Schlee-Guimaraes, Alexander Kirchhoff, Christian Urban, Antonio Piras, Alexey Stukalov, Stefan Juranek, Michael Engelke, Volker Boehm, Niels H. Gehring, Gunther Hartmann, Andreas Pichlmair, Caroline C. Friedel, , Martin Schlee

This study shows that CMTR1-mediated N1-2'O-methylation prevents antiviral recognition and regulates NVL2 mRNA splicing, affecting cell size, division, and ribosome biogenesis.

bioRxiv · Sep 28, 2023 · PreprintMolecular Biology