HIFalpha isoform specific activities drive cell-type specificity of VHL-associated oncogenesis
Joanna D.C.C. Lima, Madeleine Hooker, Ran Li, Ayslan Batista Barros, Norma Masson, Christopher William Pugh, David Robert Mole, Julie Adam, Peter John Ratcliffe, Samvid Kurlekar
The paper investigates how HIF1A and HIF2A isoforms drive cell-type specific oncogenesis in VHL disease by analyzing their roles in renal cell proliferation.
Nature Communications · Oct 16, 2025Peer-reviewedCancer Biology