Discrete genetic effects of VHL and PBRM1 inactivation co-operate to disrupt epithelial homeostasis and promote ccRCC
Samvid Kurlekar, Joanna D.C.C. Lima, Niklas Kupfer, Christopher William Pugh, David Robert Mole, Julie Adam, Peter John Ratcliffe
This study investigates how VHL and PBRM1 inactivation cooperate to disrupt epithelial homeostasis and promote ccRCC by analyzing their effects on transcription and tissue structure in vivo.
bioRxiv · Feb 20, 2026 · PreprintCancer Biology