Peter John Ratcliffe

The paper investigates the effect of oxidative stress on RGS4 and 5 stability, finding that physiological stress does not affect their stability, but cytotoxic stress increases their stability independently of the Cys N-degron pathway.

This study investigates how VHL and PBRM1 inactivation cooperate to disrupt epithelial homeostasis and promote ccRCC by analyzing their effects on transcription and tissue structure in vivo.

The paper investigates how HIF1A and HIF2A isoforms drive cell-type specific oncogenesis in VHL disease by analyzing their roles in renal cell proliferation.

This study identifies gene expression changes in the carotid body transcriptome across developmental stages in sheep, correlating with the maturation of oxygen chemosensitivity.

This study shows that HIF-2 activation induces oxygen chemosensitivity in adult adrenal medulla cells, similar to carotid body Type I cells.

The paper measures absolute translational efficiency in kidney cancer cells to show how HIF and mTOR pathways interact, finding distinct effects on gene expression and suggesting combined inhibitor use.

The paper identifies SIN3A's role in hypoxia-induced transcriptional changes, showing it represses 75% of hypoxia-repressed genes and inhibits 47% of hypoxia-induced genes.