BRC-2/BRCA2-RIPR-1 mediated constraints on homologous recombination execution are spatiotemporally regulated during meiosis
Nicola Silva, Mário Špı́rek, Magdalena Ledvinova, Neeraj Bhavani Aniyan Bhavana, Jitka Blazícková, Sowmya Sivakumar Geetha, Verena Jantsch, Lumír Krejčí
This study identifies RIPR-1 as a novel BRC-2/BRCA2 interactor that regulates RAD-51 recruitment during meiotic homologous recombination, revealing BRCA2-independent pathways and stage-dependent constraints on DNA repair.
bioRxiv · Jun 19, 2026 · PreprintCell Biology