Verena Jantsch

CIP2A tetramerization is required for mitotic DNA repair

This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.

ZHP-2/HEI10 generates CO precursors and triggers procrossover factor coarsening and CO formation through Polo kinase recruitment

This study shows ZHP-2/HEI10 regulates CO formation in C. elegans by disassembling proCO factors and recruiting Polo kinase to trigger coarsening and crossover execution.

BRC-2/BRCA2-RIPR-1 mediated constraints on homologous recombination execution are spatiotemporally regulated during meiosis

This study identifies RIPR-1 as a novel BRC-2/BRCA2 interactor that regulates RAD-51 recruitment during meiotic homologous recombination, revealing BRCA2-independent pathways and stage-dependent constraints on DNA repair.

A DIA-based quantitative crosslinking mass spectrometry framework for dynamic structural proteomics

This paper introduces DIA-QCLMS, a framework for quantitative crosslinking mass spectrometry that improves confidence assessment and integrates structural features, showing improved reproducibility in analyzing protein dynamics.

Dbf4-dependent kinase promotes meiotic DNA end resection through cyclin-dependent kinase 12 and DNA-2 in Caenorhabditis elegans

This study identifies a DDK/CDK-12/DNA-2 signaling axis that promotes meiotic DNA end resection in C. elegans, preventing aberrant recombination outcomes.

Poly(ADP-ribose) glycohydrolase promotes formation and homology-directed repair of meiotic DNA double-strand breaks independent of its catalytic activity

This study identifies PARG's role in promoting meiotic DNA break formation and repair in C. elegans, independent of its catalytic activity.

The BRCA1-BARD1 complex associates with the synaptonemal complex and pro-crossover factors and influences RAD-51 dynamics during Caenorhabditis elegans meiosis

This study investigates the localization and function of the BRCA1-BARD1 complex during Caenorhabditis elegans meiosis, showing its association with crossover factors and role in RAD-51 recruitment.