Author

Lumír Krejčí

Masaryk UniversityORCID 0000-0002-4732-1405Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Victoria MariniiD· 2 shared Alexandra Sisáková· 1 shared Benoît CarbainiD· 1 shared Boyu DingiD· 1 shared Claus M. AzzaliniD· 1 shared Diala Shatleh· 1 shared F. Javier Aguado· 1 shared Fedor Nikulenkov· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Victoria MariniORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

GenomicsbioRxivPreprintSep 15, 2026

An integrated genome-wide resource reveals distinct replication environments of DNA breakage in human cancer cell lines

Boyu Ding, Li-Chin Wang, Lorenzo Corazzi…·Pei‐Chi Wei

The paper identifies replication environments associated with DNA breakage in cancer cell lines by integrating genomic and transcriptomic data.

DOI 10.64898/2026.09.10.750571

humanbulk RNA-seq

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Cell BiologybioRxivPreprintJun 19, 2026

BRC-2/BRCA2-RIPR-1 mediated constraints on homologous recombination execution are spatiotemporally regulated during meiosis

Nicola Silva, Mário Špı́rek, Magdalena Ledvinova…·Lumír Krejčí

This study identifies RIPR-1 as a novel BRC-2/BRCA2 interactor that regulates RAD-51 recruitment during meiotic homologous recombination, revealing BRCA2-independent pathways and stage-dependent constraints on DNA repair.

DOI 10.64898/2026.06.19.733317

C. elegansDNA methylation

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Molecular BiologyJournal of Medicinal ChemistryPeer-reviewedFeb 25, 2026

Discovery of two structurally distinct classes of inhibitors targeting the nuclease MUS81 and enhancing efficacy of chemotherapy in cancer cells

Jana Prochazkova, Benoît Carbain, Victoria Marini…·Lumír Krejčí

This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.

1 citation

experimental assaydrug response / drug discovery

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Molecular BiologyNucleic Acids ResearchPeer-reviewedJun 4, 2024

Concurrent D-loop cleavage by Mus81 and Yen1 yields half-crossover precursors

Raquel Carreira, Tomás Lama-Díaz, Maria Crugeiras…·Miguel G. Blanco

The paper shows that Mus81 and Yen1 cleave D-loops to form half-crossover precursors in budding yeast.

1 citation

yeastexperimental assay

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