Nicola Silva

This study identifies RIPR-1 as a novel BRC-2/BRCA2 interactor that regulates RAD-51 recruitment during meiotic homologous recombination, revealing BRCA2-independent pathways and stage-dependent constraints on DNA repair.

The paper investigates genetic and physical interactions of DSB factors in C. elegans, revealing HIM-5's role in X-chromosome-specific crossovers and its dependency on DSB-1.

This study identifies a role for the TRiC/CCT chaperonin in folding meiotic HORMAD proteins into chromosome axes necessary for crossing over.

This study shows that in C. elegans male spermatogenesis, crossover-promoting factors can recruit to chromosomes without SPO-11 activity, indicating weakened crossover control compared to hermaphrodite oogenesis.

This study shows that DUO-1, a deubiquitinase in C. elegans, is essential for maintaining meiotic chromosome structures throughout prophase, ensuring proper meiosis.

This study identifies BRA-2 and HIM-17 as distinct factors involved in meiotic synapsis licensing and homolog pairing in C. elegans.

This study identifies a functional module involving BRC-1/BRD-1 and PARG-1 that regulates DNA repair pathway choice during meiosis in C. elegans.

This study identifies PARG's role in promoting meiotic DNA break formation and repair in C. elegans, independent of its catalytic activity.

This study investigates the localization and function of the BRCA1-BARD1 complex during Caenorhabditis elegans meiosis, showing its association with crossover factors and role in RAD-51 recruitment.