Family-GWAS reveals effects of environment and mating on genetic associations
Tammy Tan, Hariharan Jayashankar, Junming Guan, Seyed Moeen Nehzati, Mahdi Mir, Michael Bennett, Esben Agerbo, Rafael Ahlskog, Ville Anapaz, Stefania Benónísdóttir, Dorret Irene Boomsma, Archie I Campbell, Christopher F. Chabris, Zhengming Chen, China Kadoorie Biobank Collaborative Group, , Alexander I. Young
Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.
medRxiv · Oct 1, 2024 · PreprintGenetic & Genomic Medicine✦ In-depth digest