Antti Latvala

This study examines how genetic risk scores for alcohol use behaviors change over time across multiple cohorts, finding varying associations with drinking patterns and trajectories.

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

This study uses polygenic risk scores to predict substance use disorders in two samples, finding increased risk with higher scores but limited clinical utility.

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.