Rafael Ahlskog

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

The paper shows that the effect of a polygenic index of cognitive performance on economic ideology depends on class background, finding sign-discordant gene-by-environment interactions.

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.