Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2
Juveriya Qamar Khan, Karthic Rajamanickam, Frederick S. Vizeacoumar, Mahrokh Balouchi, Yue Zhang, Hussain Elhasasna, Megha Rohamare, He Dong, Kathleen K. M. Glover, Tristan Anderson-Woodsworth, Kalpana Kalyanasundaram Bhanumathy, Jocelyne M. Lew, Franco J. Vizeacoumar, Darryl Falzarano, Anil Kumar, Joyce A. Wilson
This study identifies four host-directed drugs and the NRAS/Raf/MEK/ERK pathway as critical for SARS-CoV-2 replication through CRISPR knockout screens in human lung cells.
npj Viruses · Jul 22, 2026Peer-reviewedMicrobiology