Author

Karthic Rajamanickam

University of SaskatchewanORCID 0000-0001-6863-8084Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Franco J. VizeacoumariD· 3 shared Frederick S. VizeacoumariD· 3 shared Hussain ElhasasnaiD· 3 shared Kalpana Kalyanasundaram BhanumathyiD· 3 shared Alain Morejon Morales· 2 shared Anand KrishnaniD· 2 shared Andrew FreywaldiD· 2 shared Anil KumariD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersMicrobiology

Franco J. VizeacoumarORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Microbiologynpj VirusesPeer-reviewedJul 22, 2026

Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2

Juveriya Qamar Khan, Karthic Rajamanickam, Frederick S. Vizeacoumar…·Joyce A. Wilson

This study identifies four host-directed drugs and the NRAS/Raf/MEK/ERK pathway as critical for SARS-CoV-2 replication through CRISPR knockout screens in human lung cells.

DOI 10.1038/s44298-026-00213-5

humangenetic perturbation / CRISPR

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Cancer BiologyCell GenomicsPeer-reviewedMay 9, 2025

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

Chelsea E. Cunningham, Frederick S. Vizeacoumar, Yue Zhang…·Franco J. Vizeacoumar

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

8 citations

humanCRISPR screen

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Cancer BiologybioRxivPreprintJan 26, 2025

Epigenetic Control of TERRA by FTSJ3 is Critical for Telomerase-Driven Cancers

Jared D. W. Price, Frederick S. Vizeacoumar, Omar Abuhussein…·Franco J. Vizeacoumar

The paper identifies FTSJ3 as a critical vulnerability in hTERT-overexpressing cancers by showing its role in TERRA methylation and telomeric heterochromatin stability.

3 citations

humanDNA methylation

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Molecular BiologyVirusesPeer-reviewedMay 30, 2023

Generation of a SARS-CoV-2 reverse genetics system and novel human lung cell lines that exhibit high virus-induced cytopathology

Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam…·Joyce A. Wilson

This paper develops a SARS-CoV-2 reverse genetics system and lung cell lines for studying virus replication, antiviral screening, and host interactions.

10 citations

humanexperimental assay

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