Darryl Falzarano

This study identifies four host-directed drugs and the NRAS/Raf/MEK/ERK pathway as critical for SARS-CoV-2 replication through CRISPR knockout screens in human lung cells.

This study generates and characterizes bat cell lines from Carollia perspicillata to study viral susceptibility and innate immune responses, showing their utility for virological research.

This study compares SARS-CoV-2 and MERS-CoV infection dynamics and antiviral responses in primary lung organoid-derived monolayers and air-liquid interface cultures, finding that ALI cultures better capture viral infection and immune responses.

This paper develops a SARS-CoV-2 reverse genetics system and lung cell lines for studying virus replication, antiviral screening, and host interactions.

The paper identifies four Neanderthal introgressed alleles on chromosome 3 that may modulate the regulation of CCR1 and CCR5, contributing to severe COVID-19 risk.