Author

Hussain Elhasasna

University of SaskatchewanORCID 0000-0002-2810-3138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

Frederick S. VizeacoumariD· 4 shared Anand KrishnaniD· 3 shared Andrew FreywaldiD· 3 shared Ashtalakshmi Ganapathysamy· 3 shared Franco J. VizeacoumariD· 3 shared He DongiD· 3 shared Jared D. W. PriceiD· 3 shared Kalpana Kalyanasundaram BhanumathyiD· 3 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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4 shared papersCancer Biology

Frederick S. VizeacoumarORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2

Juveriya Qamar Khan, Karthic Rajamanickam, Frederick S. Vizeacoumar, Mahrokh Balouchi, Yue Zhang, Hussain Elhasasna, Megha Rohamare, He Dong, Kathleen K. M. Glover, Tristan Anderson-Woodsworth, Kalpana Kalyanasundaram Bhanumathy, Jocelyne M. Lew, Franco J. Vizeacoumar, Darryl Falzarano, Anil Kumar, Joyce A. Wilson

This study identifies four host-directed drugs and the NRAS/Raf/MEK/ERK pathway as critical for SARS-CoV-2 replication through CRISPR knockout screens in human lung cells.

npj Viruses · Jul 22, 2026Peer-reviewedMicrobiology

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

Chelsea E. Cunningham, Frederick S. Vizeacoumar, Yue Zhang, Liliia Kyrylenko, Simon Both, Vincent Maranda, He Dong, Jared D. W. Price, Peng Gao, Konrad Wagner, Yingwen Wu, Mary Lazell-Wright, Ashtalakshmi Ganapathysamy, Rithik Hari, Kalpana Kalyanasundaram Bhanumathy, , Franco J. Vizeacoumar

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Cell Genomics · May 9, 2025Peer-reviewedCancer Biology

A novel role for Neurog2 in MYCN driven neuroendocrine plasticity of prostate cancer

Prachi Walke, Jared D. W. Price, Frederick S. Vizeacoumar, Nickson Joseph, Vincent Maranda, Bari Chowdhury, Jay Patel, Yue Zhang, He Dong, Lara New, Ashtalakshmi Ganapathysamy, Li Hui Gong, Mary Lazell-Wright, Hussain Elhasasna, Kalpana Kalyanasundaram Bhanumathy, , Franco J. Vizeacoumar

This study identifies Neurog2 as a potential therapeutic target for MYCN-driven neuroendocrine prostate cancer by showing its role in promoting tumor growth and NEPC development.

Oncogene · Apr 29, 2025Peer-reviewedCancer Biology

Epigenetic Control of TERRA by FTSJ3 is Critical for Telomerase-Driven Cancers

Jared D. W. Price, Frederick S. Vizeacoumar, Omar Abuhussein, Vincent Maranda, Yue Zhang, Hironori Adachi, Liliia Kyrylenko, Aline Rangel Pozzo, He Dong, Li Hui Gong, Prachi Walke, Ashtalakshmi Ganapathysamy, Connor Denomy, Tanya Freywald, Renuka Dahiya, , Franco J. Vizeacoumar

The paper identifies FTSJ3 as a critical vulnerability in hTERT-overexpressing cancers by showing its role in TERRA methylation and telomeric heterochromatin stability.

bioRxiv · Jan 26, 2025 · PreprintCancer Biology