KDM6B inhibition modulates monocyte activation and alleviates IMQ-psoriasis skin inflammation
Aman Damara, Najla Abassi, Delia Mihaela Mihoc, Mahsa Nastaranpour, Pauline Kraft, Tina Sarkar, Carsten Deppermann, Johannes U. Mayer, Stephan Grabbe, Michael Delacher, Fédérico Marini, Fatemeh Zare Shahneh
This paper shows that inhibiting KDM6B reduces monocyte activation and skin inflammation in a psoriasis model by restoring H3K27me3 and suppressing inflammatory gene expression.
bioRxiv · Oct 13, 2025 · PreprintImmunology