Activity-dependent synthesis of translational machinery through dynamic remodeling of ribonucleoprotein granules
Toshiharu Ichinose, Mai Kanno, Takashi T Makino, Yuichi Shichino, Shintaro Iwasaki, Hiromu Tanimoto
The paper uses optogenetic stimulation and Ribo-seq in Drosophila to show that neuronal activity triggers two phases of translation: one for synaptic factors and another for ribosomal proteins, regulated by TOP motifs and La-related protein.
bioRxiv · Jul 2, 2026 · PreprintNeuroscience