Shu Kondo

The paper shows that ABC transporters in Drosophila intestinal stem/progenitor cells reduce compound accumulation and enhance survival during cytotoxic stress.

The paper characterizes neuropeptide T2A-GAL4 knock-in lines in Drosophila, showing that adult GAL4 reporter patterns may not reflect ongoing activity and can have developmental effects.

The paper identifies a post-transcriptional mechanism where ribosomal protein S12 regulates Xrp1 expression through alternative splicing, leading to cell death in unfit cells.

The paper uses split-GFP reconstitution to profile presynaptic scaffold protein configurations in fly brain neurons, revealing cell-type-specific spatial patterns and learning-induced plasticity.

This study shows Zyxin and Ajuba limit Hippo signaling and promote Drosophila tissue growth by regulating junctions and Warts kinase activity.

This study identifies saITP and Gyc76C as key regulators of water balance in Drosophila hindgut via a neuroendocrine axis.

The paper shows octopamine signaling coordinates presynaptic machinery spatial patterns in Drosophila mushroom body neurons through Octβ2R and cAMP signaling, influenced by food deprivation.

This study identifies the mTOR-Z-Phae1 axis as a genetic pathway regulating stress-induced organismal death in Drosophila larvae.

The paper assesses the replicability of claims in Drosophila immunity research by analyzing 400 publications and identifying contradictory evidence.

The paper examines the expression and localization of two opposing dopamine receptors in Drosophila neurons, revealing their presynaptic enrichment and starvation-dependent regulation.

This paper investigates the role of the Drosophila ABCD1 ortholog in peroxisomal dynamics and shows that human ABCD1 overexpression inhibits peroxisomal biogenesis.

The paper shows that RHG genes Grim and Reaper control hemilineage-specific programmed cell death in Drosophila neurogenesis, shaping neural network composition and sex-specific circuits.

This paper characterizes the ITP signaling system in Drosophila, identifying ITPa as an anti-diuretic hormone that acts via the Gyc76C receptor to modulate osmoregulation and metabolic homeostasis.

The paper shows that translational regulation, particularly through 5' leader uORFs, enhances cell-type distinction in the Drosophila nervous system by preferentially translating neuronal proteins in neurons.

This study shows that Mettl1-dependent m7G tRNA modification is essential for spermatogenesis and fertility in Drosophila, as its loss leads to sterility and tRNA instability.

This study identifies a descending inhibitory mechanism of nociception in Drosophila mediated by the evolutionarily conserved neuropeptide DSK, analogous to the mammalian CCK system.

The paper shows Mod(mdg4)-N variants repress HeT-A retrotransposons by blocking subtelomeric enhancers in Drosophila ovarian cells, leading to female sterility.

The paper characterizes conserved smORFs in Drosophila melanogaster, showing diverse expression patterns and functional roles, including mitochondrial localization and embryonic translation.

This study identifies Crumbs and the apical spectrin cytoskeleton as regulators of R8 cell fate in Drosophila eye, distinct from their role in Hippo-dependent organ growth.

The paper shows that proapoptotic RHG genes and mitochondria are involved in non-apoptotic sensory neuron pruning in Drosophila.

This study identifies octopamine signaling from efferent neurons as essential for mating-induced germline stem cell proliferation in female Drosophila.

The paper shows that programmed cell death shapes neural networks in insects by reducing flight interneuron populations and demonstrates that blocking cell death leads to functional undead neurons.

The paper identifies genes involved in the polka-dotted fruit fly's wing pigmentation pattern through transcriptome analysis, showing co-option of neural development and signaling pathways.

This study identifies Pits and CtBP as Tgi-interacting proteins that cooperate in transcriptional repression of Hippo pathway target genes in Drosophila, with conservation in human orthologs.

The paper updates TRiP's RNAi and CRISPR fly stocks, presenting over 5,000 CRISPR-OE and -KO stocks for gene activation and knockout studies in Drosophila.

The paper identifies Tailless as a master regulator maintaining neuroblast identity and shows its inactivation stabilizes intermediate progenitor commitment during neurogenesis.

This study shows environmental light is essential for long-term memory maintenance in Drosophila by activating CREB in mushroom bodies via the Pdf signaling pathway.

This study shows that NPFR in Drosophila prothoracic gland regulates development by modulating ecdysone production and insulin signaling, linking feeding behavior to developmental timing.

This study investigates the in vivo functions of BEN-solo proteins in Drosophila embryos, showing they act as insulators to partition active chromatin and regulate gene activation.

The paper identifies Nxf2 as a key component in the Piwi-piRNA pathway, showing it forms complexes that stabilize Piwi and Panx and initiate co-transcriptional silencing of target transcripts.