A bifunctional RNase H protein supports DNA replication and transcription in nucleus-forming Chimalliviridae phages
Phoolwanti Rani, Niklas Klusch, Shannon Barret, Taylor Forman, Makaela Levine, Margot Riggi, Caroline Rees, Rui Liu, Lloyd A. Hoffman, Meliné Norquist, Dwaipayan Basu, Koe Inlow, Emily G. Armbruster, Chase J. Morgan, Joe Pogliano, , Elizabeth Villa
This study identifies Rhc as a multifunctional protein essential for DNA replication and transcription in nucleus-forming phages, revealing its role in resolving R-loops and coordinating gene expression.
bioRxiv · Oct 2, 2026 · PreprintCell Biology