Margot Riggi

A bifunctional RNase H protein supports DNA replication and transcription in nucleus-forming Chimalliviridae phages

This study identifies Rhc as a multifunctional protein essential for DNA replication and transcription in nucleus-forming phages, revealing its role in resolving R-loops and coordinating gene expression.

Atonosomes, compartments involved in membrane tension decrease

The paper identifies atonosomes as tension-responsive plasma membrane-derived compartments in yeast, showing they form rapidly in response to membrane tension loss and are regulated by cell wall dynamics.

The molecular architecture of tunneling nanotubes

This study characterizes the molecular architecture of tunneling nanotubes (TNTs) using live-cell imaging and cryo-ET, revealing a complex structure with actin, microtubules, and organelles.

Molecular mechanism of M1-mediated influenza A virus assembly

This study determines the molecular mechanism of M1-mediated influenza A virus assembly by analyzing M1's conformational states and interactions in virions.

In situ structures of the ciliary tip show the multi-step mechanism of axoneme assembly

The paper visualizes axoneme assembly in situ using cryo-electron tomography and identifies conserved microtubule luminal proteins and assembly intermediates.

Multi-scale structure of chromatin condensates rationalizes phase separation and material properties

The paper investigates the structure of chromatin condensates across scales and shows how nucleosome arrangement and histone interactions influence their physical properties.

ExoSloNano: Multi-Modal Nanogold Tags for identi-fication of Macromolecules in Live Cells & Cryo-Electron Tomograms

This paper introduces nanogold probes for identifying proteins in live cells and cryo-ET tomograms, enhancing proteome accessibility for electron microscopy.

Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography

The paper develops methods to analyze chromatin condensates using cryo-electron tomography and deep learning, revealing nucleosome structures and interactions in both reconstituted and native systems.

Cryo-ET reveals the in situ architecture of the polar tube invasion apparatus from microsporidian parasites

The paper uses cryo-electron tomography to reveal the in situ architecture of the polar tube invasion apparatus in microsporidian parasites.

Making plant tissue accessible for cryo-electron tomography

This paper describes optimized cryo-ET sample preparation workflows for plant tissues, achieving subnanometer resolution through targeted FIB milling and lamella trimming.