Probing nanomechanics by direct indentation using Nanoendoscopy-AFM reveals the nuclear elasticity transition in cancer cells
Takehiko Ichikawa, Yohei Kono, Makiko Kudo, Takeshi Shimi, Naoyuki Miyashita, Tomohiro Maesaka, Kojiro Ishibashi, Kundan Sivashanmugan, Takeshi Yoshida, Keisuke Miyazawa, Rikinari Hanayama, Eishu Hirata, Kazuki Miyata, Hiroshi Kimurâ, Takeshi Fukuma
This study uses Nanoendoscopy-AFM to directly measure nuclear elasticity in cancer cells, finding increased elasticity under serum depletion and decreased elasticity with TGF-β treatment.
ACS Applied Nano Materials · Oct 12, 2025Peer-reviewedBiophysics