Yohei Kono

The paper investigates nuclear wrinkles in epithelial cells, finding they form due to geometric adaptations to mechanical stress and cell shape changes, without causing damage.

This paper develops a nanoheater-thermometer to measure subcellular temperature and monitor HSF1 responses in living cells, showing that localized heating induces HSF1 foci at lower temperatures than whole-cell heating.

OptoChaperone enables reversible, spatiotemporal control of protein condensates using light, demonstrating efficacy in regulating disease-related condensates without chemical additives or genetic modifications.

This study uses Nanoendoscopy-AFM to directly measure nuclear elasticity in cancer cells, finding increased elasticity under serum depletion and decreased elasticity with TGF-β treatment.