Rikinari Hanayama

This paper introduces Tol-mRNA, a modular mRNA platform that induces antigen-specific immune tolerance by delivering PD-L1 and TGF-β along with antigen, showing therapeutic benefits in murine models and human immune settings.

This study uses Nanoendoscopy-AFM to directly measure nuclear elasticity in cancer cells, finding increased elasticity under serum depletion and decreased elasticity with TGF-β treatment.

This paper develops an mRNA-based platform that reprograms somatic cells into designer APCs, enhancing T cell responses against tumors and demonstrating translational potential in human and mouse models.

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.