Takehiko Ichikawa

Probing nanomechanics by direct indentation using Nanoendoscopy-AFM reveals the nuclear elasticity transition in cancer cells

This study uses Nanoendoscopy-AFM to directly measure nuclear elasticity in cancer cells, finding increased elasticity under serum depletion and decreased elasticity with TGF-β treatment.

The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity

This study shows that increased cell volume and nuclear number in Aspergillus oryzae correlate with high enzyme productivity and identifies genetic and environmental factors involved.

Epithelium Stratifies via Nucleation and Growth Induced by Foam-Geometric Instability

This study identifies a mechanism for epithelial stratification analogous to a phase transition, driven by foam-geometric instability and nucleation-growth processes.

Non-junctional Cadherin3 regulates cell migration and contact inhibition of locomotion via domain-dependent opposing regulations of Rac1.

This study shows that non-junctional cadherin3 regulates cell migration and contact inhibition of locomotion by oppositely controlling Rac1 through extracellular and cytoplasmic domains without cell-cell contact.