Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genes
Rebecca Y. Wang, Glenn G. Wozniak, Xiaoting Wang, Meer Mustafa, Malak El Khatib, Elias Kahn, Peter Heutink, Hua Long, Sara Kenkare-Mitra, Arnon Rosenthal, Zia Khan, Julia Kuhn, Daniel R. Gulbranson
The paper uses CRISPR screens and Perturb-seq to identify gene programs and functional relationships in AD GWAS risk genes related to lipid and lysosomal pathways.
bioRxiv · Jul 17, 2025 · PreprintGenetics