Author

Hua Long

Alector (United States)ORCID 0000-0002-1858-7108Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Arnon RosenthaliD· 2 shared Daniel R. GulbransoniD· 2 shared Elias Kahn· 2 shared Julia Kuhn· 2 shared Peter HeutinkiD· 2 shared Rebecca Y. Wang· 2 shared Sara Kenkare-Mitra· 2 shared Xiaoting WangiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Arnon RosenthalORCID

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2 papers

Recent·Most cited

The Alzheimers Disease Risk Genes MS4A4A And MS4A6A Cooperate to Negatively Regulate Trem2 and Microglia states

Dalya Rosner, Jiahong Sun, Rita Cacace, Angie Yee, Chaitanya Wagh, Anna Rychkova, Mariah Dunlap, Daniel R. Gulbranson, Adiljan Ibrahim, Xiaoting Wang, Rebecca Y. Wang, Alice Buonfiglioli, Muhammad Alhawagri, Philip L. Kong, Marina K. Roell, , Arnon Rosenthal

This study shows that MS4A4A and MS4A6A negatively regulate TREM2 and microglial function in Alzheimer's disease, suggesting they are potential drug targets.

Neuron · Dec 22, 2025Peer-reviewedNeuroscience

Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genes

Rebecca Y. Wang, Glenn G. Wozniak, Xiaoting Wang, Meer Mustafa, Malak El Khatib, Elias Kahn, Peter Heutink, Hua Long, Sara Kenkare-Mitra, Arnon Rosenthal, Zia Khan, Julia Kuhn, Daniel R. Gulbranson

The paper uses CRISPR screens and Perturb-seq to identify gene programs and functional relationships in AD GWAS risk genes related to lipid and lysosomal pathways.

bioRxiv · Jul 17, 2025 · PreprintGenetics