Author

Julia Kuhn

Alector (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Neuroscience· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Rebecca Y. Wang· 3 shared Zia KhaniD· 3 shared Arnon RosenthaliD· 2 shared Daniel R. GulbransoniD· 2 shared Elias Kahn· 2 shared Hua LongiD· 2 shared Peter HeutinkiD· 2 shared Sara Kenkare-Mitra· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Rebecca Y. Wang

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Author profile →

4 papers

Recent·Most cited

The Human Bindome: A Proteome-scale Atlas of Designed Binder Candidates

Julius Wenckstern, Anna M. Díaz-Rovira, Julia Kuhn, Arvid Ban, Rahma Hamdani, Roser Pruano-Milla, Evgenia Elizarova, Sandrine Georgeon, Kaiden Thompson, Matthias Hinterndorfer, Devanarayanan Siva Sankar, Maximilian Dünnebacke, David Desscan, Sreenath Sasidharan Nair, Marcelo Querino Lima Afonso, , Bruno E. Correia

A parallelized BindCraft pipeline generated 306,146 in silico binder candidates against 8,296 human proteins, each with sequence, predicted complex and confidence metrics, freely accessible online.

bioRxiv · Jul 30, 2026 · PreprintSynthetic Biology✦ In-depth digest

The Alzheimers Disease Risk Genes MS4A4A And MS4A6A Cooperate to Negatively Regulate Trem2 and Microglia states

Dalya Rosner, Jiahong Sun, Rita Cacace, Angie Yee, Chaitanya Wagh, Anna Rychkova, Mariah Dunlap, Daniel R. Gulbranson, Adiljan Ibrahim, Xiaoting Wang, Rebecca Y. Wang, Alice Buonfiglioli, Muhammad Alhawagri, Philip L. Kong, Marina K. Roell, , Arnon Rosenthal

This study shows that MS4A4A and MS4A6A negatively regulate TREM2 and microglial function in Alzheimer's disease, suggesting they are potential drug targets.

Neuron · Dec 22, 2025Peer-reviewedNeuroscience

Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genes

Rebecca Y. Wang, Glenn G. Wozniak, Xiaoting Wang, Meer Mustafa, Malak El Khatib, Elias Kahn, Peter Heutink, Hua Long, Sara Kenkare-Mitra, Arnon Rosenthal, Zia Khan, Julia Kuhn, Daniel R. Gulbranson

The paper uses CRISPR screens and Perturb-seq to identify gene programs and functional relationships in AD GWAS risk genes related to lipid and lysosomal pathways.

bioRxiv · Jul 17, 2025 · PreprintGenetics

Enhancing Gene Set Overrepresentation Analysis with Large Language Models

Jiqing Zhu, Rebecca Y. Wang, Xiaoting Wang, Ricardo Azevedo, Alexander Moreno, Julia Kuhn, Zia Khan

This paper introduces llm2geneset, a framework using large language models to generate gene sets from input genes and context, improving overrepresentation analysis compared to human-curated databases.

Bioinformatics Advances · Dec 26, 2024Peer-reviewedBioinformatics