Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer
Purab Pal, Shweta Chitkara, Godwin K. Sarpey, Fouad Alani, Huiping Zhao, Malik Ata, Jun Qu, Rachel Schiff, Debra A. Tonetti, Geoffrey L. Greene, Jonna M. Frasor, Gunes Ekin Atilla‐Gokcumen, Jonathan L. Coloff
This study shows that ET-resistant breast cancer cells are more sensitive to ceramide-induced endoplasmic reticulum stress, mediated through TRAM1, leading to cell death.
bioRxiv · Aug 18, 2025 · PreprintCancer Biology