Author

Jonna M. Frasor

University of Illinois ChicagoORCID 0000-0002-6003-1867Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Debra A. TonettiiD· 2 shared Fouad AlaniiD· 2 shared Geoffrey L. GreeneiD· 2 shared Huiping ZhaoiD· 2 shared Jonathan L. ColoffiD· 2 shared Andre Kajdacsy‐BallaiD· 1 shared Godwin K. SarpeyiD· 1 shared Gunes Ekin Atilla‐GokcumeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Debra A. TonettiORCID

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2 papers

Recent·Most cited

Integrative pipeline to profile and target endocrine therapy-insensitive cell populations in ER+ breast cancer

Svetlana E. Semina, Rosemary J. Huggins, Huiping Zhao, Keiko Yanagihara, Monica Sheinin, Virgilia Macias, Fouad Alani, Leo Feferman, Andre Kajdacsy‐Balla, Debra A. Tonetti, Kent F. Hoskins, Geoffrey L. Greene, Jonna M. Frasor, Jonathan L. Coloff

The paper develops an analytical pipeline to identify and target endocrine therapy-insensitive cells in ER+ breast cancer using single-cell RNA sequencing and functional validation in organoid models.

bioRxiv · Sep 16, 2026 · PreprintCancer Biology

Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer

Purab Pal, Shweta Chitkara, Godwin K. Sarpey, Fouad Alani, Huiping Zhao, Malik Ata, Jun Qu, Rachel Schiff, Debra A. Tonetti, Geoffrey L. Greene, Jonna M. Frasor, Gunes Ekin Atilla‐Gokcumen, Jonathan L. Coloff

This study shows that ET-resistant breast cancer cells are more sensitive to ceramide-induced endoplasmic reticulum stress, mediated through TRAM1, leading to cell death.

bioRxiv · Aug 18, 2025 · PreprintCancer Biology